One of the questions I hear most often from patients and fellow clinicians is: “Do I need supplements while taking a GLP-1 medication such as Ozempic, Mounjaro, Zepbound, or Wegovy?” The answer isn’t a simple yes or no. It depends largely on the quality and quantity of food someone can eat during treatment. GLP-1 medications are not inherently nutrient-depleting, but a reduced appetite and changes in food intake and body composition can increase the risk of nutritional gaps. Let’s examine the evidence to determine who may benefit from supplements—and which ones may be worth considering.